Azathioprine Side Effects & Safe Alternatives Of Azathioprine In Ayurveda

Abstract

Azoran comes under the brand Imuran which is an immunosuppressive medication. It comes in two forms- An oral tablet and an injectable solution. It is helpful in treating various autoimmune disorders such as rheumatoid arthritis, Ulcerative colitis and Immune thrombocytopenia. It comes under the class of immunosuppressants which is useful in reducing pain and inflammation. Azoran tablets contain Azathioprine which decreases the function of the cells and causes inflammation and there is a progression over time. Immune thrombocytopenia purpura (ITP) is a low level of platelets with normal bone marrow. It causes various characteristic features such as red and purple bruises/rashes. ITP is an autoimmune disease with antibodies against several platelet surfaces. It includes formations of bruises (purpura) and Petechiae (tiny bruises) sometimes with bleeding from nostrils. Sometimes blood transfusion is used in several cases of low platelets. In this article, we are going to discuss its causes and pathophysiology in detail further in the article.

Azoran, Azathioprine, What is Azathioprine, Azoran Side Effects, Alternatives Of Azathioprine In Ayurveda, Better Options in Ayurveda, Herbal Remedies, Alternative Medicines, Herbal Supplements

Introductions

Azathioprine (AZA) is an immunosuppressive agent which is associated with the conditions such as Atopic dermatitis, Immune thrombocytopenia (ITP), and Psoriasis. It is helpful in reducing the number of flares in relapsing conditions. Azathioprine comes in the form of a tablet which is swallowed orally. It is helpful in stopping the immune system from attacking the organs. It decreases the activity of the body’s immune system. Azathioprine is helpful in preventing the rejection of the kidney and liver allografts, which get absorbed from the gut and vary from patient to patient. It is a thiopurine which is linked to the second heterocycle, which was synthesized by George Herbert Hitchings and Gertrude Elion in 1957 to produce the 6 MP in a metabolic state. Its chemical formula is C9H7N7O2S. Azathioprine was granted FDA approval in 1968.

Mechanism Of Action

It inhibits purine synthesis, which further produces DNA and RNA. Azathioprine is converted into the tissues to 6-MP, which gets converted to 6 Thioguanine in addition to the amino group. The 6 MP and 6 Thioguanine are conjugated with ribose and then form a nucleotide thioinosinic acid and Thioguanylic acid and form the building blocks of DNA and RNA.

  • The nucleotide is newly synthesised DNA and halts replications.
  • Nucleotides inhibit the enzymes which are involved in purine biosynthesis and GPAT inhibition through negative feedback known as Product inhibition.
  • The nucleotide is phosphorylated to the triphosphate form which binds to GTP binding and blocks the synthesis of protein Bcl-xL and sends the activated T cells and mononuclear cells into apoptosis.

Pharmacokinetics

The drug is inactivated in the liver, Azathioprine is a prodrug which is not an active drug but it gets activated in the body. Is an immunosuppressive agent which functions through the modulation of Rac1 to induce T-cell apoptosis. Azathioprine is 30% which gets bound to proteins in human serum albumin in the circulation. The end product of the azathioprine metabolism is thiourea acid and various hydroxylated purines which are further excreted via urine. The half-life of azathioprine is approximately 5 hours.

Various Side Effects Of Azoran

  • Nausea is the most frequent side effect
  • Fever
  • Arthralgia
  • Hepatotoxicity
  • Low white blood cells
  • Stomach problems such as Nausea, diarrhea and vomiting
  • Increase liver enzyme
  • Low blood pressure
  • Pancreatitis which includes symptoms such as Fatty stools, severe abdominal pain
  • Extreme tiredness
  • Excessive weight loss
  • Severe allergic reactions- Includes wheezing, itching and chest tightness
  • Decrease resistance to infection
  • Unusual bruising
  • Development of mouth sores and ulcers

Contraindications

  • Hypersensitivity
  • Azoran increases the risk of spontaneous recommendation
  • Breastfeeding
  • Known Malignancy
  • Active infection

Herbs Useful As Alternative Of Azaron

  1. AMALAKI: Amalaki (Emblica officinalis) is helpful in balancing tridoshas of the body and is helpful in inducing purgation and is useful in skin diseases. It is the best anti-ageing herb which improves the overall health of the eyes and various bleeding disorders. Balances tridoshas of the body and improves physical strength and complexion.
  2. BHUMI AMLA: Bhumi Amla (Phyllanthus niruri) reduces Kapha and Pitta doshas, improves the taste and in chronic respiratory disorders. Maintains the functions of the liver, Useful in bleeding disorders and in skin disorders. Reduces vitiated Kapha and Pitta doshas. Protects the lining of the stomach which is caused by excessive gastric acid. Manages the normal blood sugar level.
  3. DRAKSHA: Draksha (Vitis vinifera) balances Vata and Pitta doshas, is purgative in nature and effective in fatigues and tiredness. Rich in antioxidants and helpful in keeping the blood pure and healthy. Helpful in improving digestion and promotes strength. Relieves anorexia and alleviates skin disorders.
  4. SHIGRU: Shigru (Moringa oleifera) is helpful in balancing Vata and Kapha doshas and is helpful for the cardiac system as it reduces the high blood pressure level in the body. Improves the strength of teeth and bones so useful in bone disorders. Has anti-bacterial and anti-inflammatory properties which is helpful in quick healing.

Herbal Products To Be Used As Azaron’s Alternative

Planet Ayurveda is an Illustrious and recognized organization which makes herbal products worldwide and the formulations are prepared under the supervision of Ayurvedic expert doctors. These formulations are safe and free from any kind of adulterations, preservatives and many other chemicals. These herbal supplements act on the body and correct the imbalance of doshas without causing any side effects. Planet ayurveda provides herbal supplement which is helpful in this disease and the following medications are as follows-

PRODUCTS LIST

  1. SPIRULINA CAPSULES
  2. IMMUNE BOOSTER
  3. KUMAR KALYAN RAS
  4. GREEN ESSENTIALS
  5. PUNARNAVA MANDUR
  6. BRAHMI CHYAWANPRASH
  7. ASHWAGANDHA CAPSULES
  8. PITTA BALANCE
  9. PLATO PLAN CAPSULES
  10. JAI MANGAL RAS
Azoran, Azathioprine, What is Azathioprine, Azoran Side Effects, Alternatives Of Azathioprine In Ayurveda, Better Options in Ayurveda, Herbal Remedies, Alternative Medicines, Herbal Supplements

PRODUCTS DESCRIPTION

  1. Spirulina Capsules: Spirulina Capsules are single herbal capsules from planet ayurveda containing Spirulina (Spirulina platensis). It is helpful in boosting the immune system and provides stamina. Maintains healthy cardiovascular functions and reduces the wear-tear in the body. Reduces the severity of strokes and improves recovery after stroke. Spirulina prevents quick ageing and is helpful for all types of allergies.

    2. Dosage: 1-2 capsules twice daily with plain water after meals.

  2. Immune Booster: Immune boosters are poly-herbal capsules from planet ayurveda using various ingredients such as Grape seed (Vitis vinifera), Bhumi Amla (Phyllanthus niruri), Go-Piyush (Bovine colostrums) and Amalaki (Emblica officinalis). It is helpful in throwing out toxins from the body and protecting the body from various recurrent infections. Protects the body from free radicals and toxins.

    3. Dosage: 1-2 capsules twice daily after meals with plain water.

  3. Kumar Kalyan Ras: Kumar Kalyan Ras is a classical Ayurvedic product which is formulated by planet ayurveda using various ingredients such as Mukta Bhasma (Calx of pearl), Swarna bhasma (Calx of gold), Makshika Bhasma (Calx of copper and iron pyrite) and many more. It is useful in low immunity and providing strength to the body. Helpful in digestive problems and in general debility.

    4. Dosage: 1 tablet once daily after meals with plain water.

  4. Green Essential: Green Essential are polyherbal capsules which are made by planet ayurveda using various ingredients such as Wheat Grass (Triticulum aestivum), Green tea (Camellia sinensis), Amla (Emblica officinalis) and many more. It is helpful in supporting the healthy immune system and stimulates nerves. Has anti-inflammatory properties and is full of antioxidants.

    5. Dosage: 1-2 capsules twice daily after meals with plain water.

  5. Punarnava Mandur: Punarnava Mandur are herbal tablet formulation made by planet ayurveda using Punarnava (Boerhaavia diffusa), Maricha (Piper nigrum), Haridra (Curcuma longa), Chitrak Mool (Plumbago zeylanica) and many more. Helpful in maintaining the water balance in the body, Helpful in renal disorders and reduces joint pain. Expels toxins from the body and is a natural diuretic.

    6. Dosage: 1-2 tablets twice daily after meals with lukewarm water.

  6. Brahmi Chyawanprash: Brahmi Chyawanprash is a classical ayurvedic product which consists of various ingredients such as Nagarmotha (Cyperus rotundus), Jeerak (Cuminum cyminum), Vidarikand (Pueraria tuberosa), Choti Elachi (Elettaria cardamomum) and many more. It has anti-inflammatory and antioxidant properties. It is helpful in urinary disorders and has the quality of detoxification.

    7. Dosage: 1-2 teaspoons twice daily after meals.

  7. Ashwagandha Capsules: Ashwagandha Capsules are single herbal capsules which are made by Planet Ayurveda using Ashwagandha (Withania somnifera). It is helpful in bringing strength to the muscles and calms down the system. Act as a nervous tonic which enhances stamina. Helpful in reducing swelling and restores the blood supply.

    8. Dosage: 1-2 capsules twice daily with plain water after meals.

  8. Pitta Balance: Pitta Balance are polyherbal Capsules which is made by planet ayurveda which maintain a healthy digestive system and contains various ingredients such as JaharMohra Pishti (Natural calcium compound), Akik Pishti (Natural calcium compound), Giloy Satva (Tinospora cordifolia) and many more. Helpful in maintaining and supporting healthy joints. It is helpful in controlling anger and anxiety.

    9. Dosage: 1 Capsule twice daily with plain water after meals.

  9. Plato Plan Syrup: Plato Plan Syrup are herbal syrup which is made by planet ayurveda using various ingredients such as Giloy (Tinospora cordifolia), Draksha (Vitis vinifera), Ashwagandha (Withania somnifera) and many more. It is helpful in increasing the number of platelets and boosts the immune system. It is enriched in the early destruction of platelets.

    10. Dosage: 1-2 teaspoons twice daily after meals.

  10. Jai Mangal Ras: Jai Mangal Ras is a classical Ayurvedic product which is made by planet ayurveda using various ingredients such as Shuddha Gandhaka (Purified and processed sulphur), Saindhava Lavan (Rock salt), Loha Bhasma (Calx of Iron), Vanga Bhasma (Calx of Tin) and many more. Helpful in the treatment of viral infections and useful in boosting immunity. Balances tridoshas of the body.

    11. Dosage: 1 tablet twice daily after meals.

Conclusion

Azoran comes under the brand Imuran which is an immunosuppressive medication. It comes in two forms – An oral tablet and an injectable solution. It is helpful in treating various autoimmune disorders such as rheumatoid arthritis, Ulcerative colitis and Immune thrombocytopenia. was synthesized by George Herbert Hitchings and Gertrude Elion in 1957 to produce the 6 MP in a metabolic state. Its chemical formula is C9H7N7O2S. Azathioprine was granted FDA approval in 1968. In ayurveda, Immune thrombocytopenia purpura is correlated with Raktapitta bleeding disorders where the rakta (blood) is vitiated with Pitta doshas (especially Ranjak pitta) which comes out from the orifices of the body. Further, we discussed ITP LEVEL-2 (PLATELET GUSH PACK) which is made by planet ayurveda and is helpful in this disease without causing any side effects.