Introduction
Anaemia is defined as a reduction in the blood’s ability to carry oxygen, Which is measured in the laboratory as a low haemoglobin concentration, or a low hematocrit (the percentage of the blood volume that is occupied by red blood cells or erythrocytes). In a normal person, the haemoglobin is approximately 13 grams per decilitre and the hematocrit is approximately 40%.
Anaemia is not a disease as such, but a reflection of some other problem. It occurs when the balance between the normal rates of blood loss and blood production is disturbed. There are three basic mechanisms by which this occurs:
- Blood loss
- Increased destruction of red blood cells (haemolysis)
- Decreased Red Blood Cell production
Anaemia in Renal Failure: Causes and Mechanisms
In a person with normal renal function, the finding of anaemia on routine blood analysis would lead to further investigations to identify the underlying cause. In chronic renal failure, anaemia is commonly observed, and can result from any of the mechanisms mentioned above. However, the typical “anaemia of chronic renal insufficiency” is a result of a decreased production of red blood cells by the bone marrow.
Impaired Red Blood Cell Production in Chronic Renal Failure
This defect in red blood cell production is largely explained by the inability of the failing kidneys to secrete the hormone erythropoietin. This hormone is a necessary stimulus for normal bone marrow to produce red blood cells. In addition, other factors associated with renal failure, including the accumulation of so-called uremic toxins, may play a role in depressing bone marrow function. Excessive accumulation of aluminium can occur in the bone marrow of patients on long-term dialysis, which may also contribute to the development of anaemia.
Blood Loss and Red Blood Cell Destruction in Renal Failure
Blood loss and red blood cell destruction also frequently contribute to the anaemia in patients with renal failure. Platelets, which are small constituents of blood which aid in blood clotting; do not work normally in uraemia. The defective blood clotting seen in uraemia makes bleeding more common. Rapid bleeding from an ulcer in the gastrointestinal tract, for example, causes a rapid decrease in the hematocrit and is a medical emergency. Very slow loss of blood can also cause anaemia by depleting the body’s stores of iron, which the bone marrow uses to produce blood cells.
Premature Destruction of Red Blood Cells (Haemolysis)
Excessive destruction of red blood cells is also seen in advanced renal failure. Normally, red blood cells survive for about four months before being destroyed. This life span is reduced in renal failure, probably because of chemical effects of uraemia and decreased flexibility of the red blood cells. This haemolysis is usually mild and a person with a normal bone marrow could easily compensate for it by increasing red blood cell production. However, in renal failure, the bone marrow’s capacity to compensate is diminished.
What is the Role of Haemodialysis in the Anaemia of Chronic Renal Failure?
The effectiveness of dialysis in reversing uraemic complications depends on the specific nature of the disturbance. Complications caused by the accumulation of uremic toxins may be reversible if the toxin is dialyzable and if the dialysis removes it more quickly than it is generated. Some improvement in red blood cell production can occur with the initiation of dialysis, likely due to a reduction in the toxic impact of uraemia on the bone marrow. However, dialysis does not replace the kidney’s hormone-producing functions, meaning it cannot correct the primary cause of anaemia, which is insufficient erythropoietin production. While dialysis can alleviate the bleeding tendency associated with uraemia, it does not fully normalize platelet function.
Dialysis itself may also contribute to the anaemia. Iron deficiency can result from unavoidable dialyzer blood loss, clotted dialysis membranes, and frequent blood sampling. Haemolysis may occur if there are problems with the dialysate (temperature problems, contamination with aluminium, fluoride, copper, chlorine, or chloramines). Folate, a water soluble vitamin necessary for normal red blood cell production, is dialyzable. Generally, dialysis patients are given oral supplementation with folic acid in case their normal diet does not supply them with sufficient folate to keep up with its loss through dialysis.
Most patients tolerate chronic anaemia fairly well. In an otherwise healthy patient with chronic renal failure, a hematocrit of approximately 25% is typical. The presence of other medical problems, particularly heart and lung disease, can decrease a patient’s ability to tolerate a lower blood count. Patients who have undergone bilateral kidney removal (Nephrectomy) often have hematocrits which are significantly lower, probably because they cannot make any erythropoietin at all. Patients whose kidney failure is a result of polycystic kidney disease generally do not have anaemia.
The treatment of the anaemia of chronic renal failure has changed dramatically in recent years. Until recently, the principal treatments were transfusion of red blood cells and administration of the hormone testosterone. Although transfusions will rapidly correct a low blood count, repeated transfusions are associated with some problems, including iron overload, the development of certain antibodies, and the possibility of viral infections. Testosterone may stimulate red blood cell production by the bone marrow, but the effect is generally small, and its use is often associated with virilising side effects.
Effective Herbal Remedy For CKD
Rencure Formula
Planet Ayurveda Rencure Formula is an Ayurvedic herbal supplement specifically formulated to support kidney health and address various kidney-related issues, including kidney stones and kidney function. This product contains a blend of potent herbs known for their detoxifying, diuretic, and healing properties. It aims to support the kidneys’ natural detoxification processes, improve urinary health, and help prevent kidney damage. Below is a detailed explanation of the Rencure Formula.
Key Features of Planet Ayurveda Rencure Formula
1. Kidney Health Support
The primary purpose of Rencure Formula is to enhance the health of the kidneys by supporting their detoxification processes and improving overall kidney function.
2. Herbal Detoxification
The herbs in this formula act as natural detoxifiers, helping the kidneys filter and remove toxins from the body, which may reduce the load on the kidneys and prevent further damage.
3. Prevention of Kidney Stones
Rencure Formula contains ingredients that help dissolve kidney stones and prevent new ones from forming by maintaining proper urinary pH levels and supporting the breakdown of stone-forming compounds.
4. Urinary Health
This formula supports the proper functioning of the urinary system, promoting healthy urine flow, reducing urinary tract infections (UTIs), and managing issues like frequent urination.
5. Natural Ingredients
The Rencure Formula is made from a blend of natural herbs that have been used in Ayurveda for centuries to support kidney function and overall health.
Ingredients of Rencure Formula
| S. No. | Herb Used | Latin Name | Part Used | Quantity |
| 1. | Punarnava | Boerhavia diffusa | Root | 200 mg |
| 2 | Varun | Crataeva nurvala | Bark | 100 mg |
| 3. | Gokshura | Tribulus terrestris | Whole | 100 mg |
| 4. | Palaash | Butea monosperma | Bark | 50 mg |
| 5. | Kaasni | Cichorium intybus | Root | 50 mg |
Key Ingredients of Planet Ayurveda Rencure Formula
1. Punarnava (Boerhavia diffusa)
Known for its diuretic properties, Punarnava helps in improving kidney function and reducing fluid retention. It aids in the natural elimination of toxins from the body and is commonly used to treat kidney and urinary tract conditions.
2. Gokshura (Tribulus terrestris)
Gokshura is an herb that helps promote healthy kidney function, reduce swelling, and improve urinary health. It is also known for its anti-inflammatory properties and supports the proper functioning of the urinary tract.
3. Varuna (Crataeva nurvala)
Varuna is used in Ayurveda for its ability to support kidney function, relieve pain caused by kidney stones, and prevent the formation of kidney stones. It also helps in improving urinary flow.
Health Benefits of Planet Ayurveda Rencure Formula
1. Supports Kidney Function:
The combination of ingredients helps maintain healthy kidney function, improve the filtration capacity of the kidneys, and detoxify the blood.
2. Prevents and Treats Kidney Stones
Rencure Formula helps in breaking down kidney stones and reducing the risk of new stones forming by improving the overall health of the urinary tract and kidneys.
3. Improves Urinary Health
It promotes healthy urine flow, relieves symptoms of urinary tract infections (UTIs), reduces pain and discomfort associated with kidney stones, and helps improve the overall health of the urinary system.
4. Reduces Inflammation and Pain
The anti-inflammatory properties of the herbs in Rencure Formula help reduce inflammation in the kidneys and urinary tract, alleviating discomfort and pain associated with kidney issues.
5. Detoxifies the Body
The herbal ingredients support detoxification by helping to eliminate waste products and toxins from the kidneys, which can prevent further damage to the kidney tissues.
6. Supports Overall Kidney Health
Rencure Formula helps improve kidney health and function by enhancing blood circulation to the kidneys, regulating fluid balance, and protecting the kidneys from oxidative stress and damage.
How to Use Rencure Formula
1. Dosage
- The typical dosage is 1-2 capsules, two times a day after meals, or as directed by a healthcare professional.
- The dosage may vary based on the severity of the condition and individual health needs, so it’s important to follow the instructions on the product packaging or consult a healthcare provider.
2. When to Take
It’s recommended to take Rencure Formula after meals with warm water to ensure proper absorption of the herbs.
3. Duration of Use
For best results, it’s important to take Rencure Formula regularly, often for a period of several weeks or months, depending on the individual’s condition. Consultation with an Ayurvedic practitioner can help determine the ideal duration of use.
To buy Rencure Formula, please visit store.planetayurveda.com/products/rencure-formula
Precautions and Side Effects
- Consultation with a healthcare provider is recommended before using Rencure Formula, particularly for individuals who are pregnant, breastfeeding, or taking prescription medications.
- This product is generally safe due to its natural herbal ingredients; however, people who are allergic to any of the herbs should avoid using it.
- If you have any underlying medical conditions, such as kidney disease, or are undergoing treatment for kidney-related issues, it’s essential to discuss the use of this formula with a doctor.
